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. 2014 Mar 28;33(9):1011–1026. doi: 10.1002/embj.201387009

Figure 2. OMA1 ablation does not rescue mitochondrial transport defect of AFG3L2-depleted neurons.

Figure 2

  • Representative kymographs of axons (shown above respective kymographs) from neurons isolated from Oma1 knockout mice co-transfected with mito-mCherry and control or Afg3l2 siRNAs. Schematic of different color-coded transport types is shown below. Scale bars, 10 μm.
  • The percentage of mitochondria belonging to a given length bin was averaged from three independent experiments (105–200 mitochondria were measured in each experiment). Bars represent SEM.
  • Quantification of mitochondrial occupancy per axon (n = 3 experiments; at least 8 axons per experiment).
  • Quantification of mitochondrial transport types in the axon. Data represent mean ± SEM of three independent experiments. At least 8 axons from each experiment were analyzed. P-value was determined with Student's t-test.