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The amount of 5-FU in an aqueous solution diffused through full thickness mouse skin treated (•) or not treated (○) with microneedles as a function of time. Data shown are means±S.E.M (n=3). At all the time points tested, with the exception of 0 h, the values between the microneedle-treated and -untreated groups are significantly different (P<0.05).
