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. 2014 Oct 1;6:21. doi: 10.1186/2045-824X-6-21

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Copyright © 2014 Herring et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Schematic representation of the mTmG reporter strain. The mTmG reporter mice (Jackson strain: B6.129 (Cg)-Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/J ) contain a single copy of the transgene integrated into the ROSA 26 locus. The transgene cassette is comprised of a chimeric CMV, β-actin promoter driving the expression of a floxed membrane localized Tomato tandem dimer. Following cre-mediated excision the mTomato transgene is removed such that the CAG promoter now drives expression of membrane localized EGFP. The reporter mice were crossed with transgenic mice that express a tamoxifen regulated cre recombinase directed to smooth muscle cells by either the Myh11 promoter or the Acta2 promoter. Double heterozygous transgenic mice were used for all experiments.