Skip to main content
. Author manuscript; available in PMC: 2015 Jan 14.
Published in final edited form as: AIDS. 2014 Jan 14;28(2):181–186. doi: 10.1097/QAD.0000000000000123

Table 2.

Cox proportional hazard models of virologic failure defined as HIV-1 RNA rebound >50 copies/mL, ≥200 copies/mL, or ≥1,000 copies/mL.

Virologic Failure Definition Factors Univariate Multivariable
HR [95% CI] P-value HR [95% CI] P-value
VL>50 copies/mL Detectable RV1 2.08 [1.13–3.81] 0.02 1.58 [0.85–2.93] 0.15
CD4+ cell count2 1.05 [0.99–1.11] 0.10 1.05 [0.99–1.12] 0.11
ART adherence3 1.21 [1.12–1.32] <0.001 1.21 [1.11–1.33] <0.001
Substance abuse4 1.83 [1.0–3.35] 0.049 1.57 [0.84–2.93] 0.16
VL ≥200 copies/mL Detectable RV1 1.55 [0.74–3.22] 0.24 1.19 [0.57–2.49] 0.65
CD4+ cell count2 1.08 [1.0–1.16] 0.05 1.10 [1.02–1.19] 0.02
ART adherence3 1.14 [1.05–1.23] 0.003 1.19 [1.07–1.31] <0.001
Substance abuse4 2.31 [1.12–4.74] 0.02 1.70 [0.82–3.56] 0.16
VL≥1000 copies/mL Detectable RV1 1.86 [0.78–4.43] 0.16 1.40 [0.58–3.41] 0.45
CD4+ cell count2 1.07 [0.99–1.17] 0.11 1.10 [1.00–1.21] 0.04
ART adherence3 1.14 [1.03–1.25] 0.007 1.17 [1.06–1.31] 0.003
Substance abuse4 1.54 [0.66–3.56] 0.32 1.07 [0.45–2.53] 0.88
1

Detectable residual viremia by the single-copy assay.

2

Per 50 CD4+ cell/ul decrease.

3

Average past 2 months, per 5% decrease in adherence.

4

Any drug use in the past 3 months or hazardous alcohol use in the past month.

Abbreviations: HR, hazard ratio; VL, viral load; RV, residual viremia.