Table 2.
Patient characteristics at CRRT initiation and outcomes
| Average intensity, mL/kg/h | |||||
|---|---|---|---|---|---|
| <10 | 10 to 15 | 15 to 20 | >20 | P -value | |
| Vasopressor use | 54 (84.4%) | 92 (66.7%) | 45 (66.2%) | 32 (69.6%) | 0.06 |
| Mean arterial pressure, mmHg | 73 (65, 84) | 71 (60, 80) | 73 (64, 83) | 67 (57, 80) | 0.23 |
| Mechanical ventilation | 53 (82.8%) | 111 (80.4%) | 58 (85.3%) | 41 (89.1%) | 0.55 |
| PaO2/FiO2 ratio, Torr | 215 (152, 300) | 197 (136, 300) | 226 (134, 331) | 208 (125, 336) | 0.83 |
| Lactate, mmol/L | 2.4 (1.5, 5.7) | 2.5 (1.4, 5.2) | 2.4 (1.4, 4.3) | 3.4 (1.5, 8.0) | 0.61 |
| Glasgow coma scale | 14 (11, 15) | 14 (10, 15) | 14 (9, 15) | 12 (6, 15) | 0.05 |
| Platelet count, 103/μL | 107 (59, 163) | 90 (52, 142) | 84 (51, 156) | 88 (56, 154) | 0.55 |
| Bilirubin, mmol/L | 20.5 (12.0, 54.7) | 18.8 (10.3, 37.6) | 15.4 (8.6, 40.6) | 17.7 (8.6, 42.3) | 0.26 |
| Diuretics use | 36 (56.3%) | 62 (44.9%) | 29 (42.7%) | 15 (28.3%) | 0.035 |
| Urine output, mL/h | 17 (5, 45) | 21 (9, 40) | 22 (9, 53) | 16 (5, 42) | 0.67 |
| Creatinine, μmol/L | 248 (159, 378) | 242 (182, 328) | 225 (163, 310) | 254 (169, 363) | 0.55 |
| Urea, mmol/L | 18.0 (11.7, 27) | 17.7 (12.1, 25.8) | 17.5 (10.7, 23.0) | 20.0 (14.3, 35.3) | 0.14 |
| ICU to start, day | 0.9 (0.2, 1.7) | 0.9 (0.2, 2.0) | 1.0 (0.2, 2.2) | 0.4 (0.1, 1.7) | 0.44 |
| Mode of CRRT | |||||
| CVVH | 6 (9.4%) | 7 (5.1%) | 1 (1.5%) | 4 (8.7%) | 0.19 |
| CVVHD | 24 (37.5%) | 33 (23.9%) | 9 (13.2%) | 8 (17.4%) | 0.008 |
| CVVHDF | 34 (53.1%) | 98 (71.0%) | 58 (85.3%) | 34 (73.9%) | 0.0008 |
| Blood flow, mL/min | 100 (80, 100) | 100 (80, 100) | 100 (80, 100) | 100 (80, 100) | 0.89 |
| CRRT dose, L/h | 0.60 (0.60, 0.80) | 0.80 (0.60, 0.8) | 1.0 (0.8, 1.0) | 1.3 (1.0, 3.0) | <0.0001 |
| Average intensity, mL/kg/h | 8.7 (7.1, 9.2) | 12.6 (11.1, 13.9) | 16.6 (15.7, 18.3) | 24.4 (20.9, 30.9) | <0.0001 |
| CRRT down time (%) | 5.8 (0, 21.3) | 1.5 (0, 6.2) | 2.6 (0.4, 5.2) | 1.5 (0, 4.0) | 0.014 |
| CRRT duration, days | 3.9 (1.9, 6.9) | 3.3 (1.7, 6.1) | 2.7 (1.7, 5.6) | 2.6 (1.3, 4.8) | 0.36 |
| ICU mortality | 30 (46.9%) | 57 (41.3%) | 24 (35.3%) | 22 (47.8%) | 0.47 |
| Hospital mortality | 35 (54.7%) | 76 (55.1%) | 35 (51.5%) | 30 (65.2%) | 0.53 |
| RRT at discharge among survivors | 7 (24.1%) | 6 (9.7%) | 3 (9.1%) | 0 (0%) | 0.09 |
Results are presented as number (%) or median (IQR), ICU to start, duration between ICU admission to continuous renal replacement therapy (CRRT) initiation; CVVH, continuous veno-venous hemofiltration; CVVHD: continuous veno-venous hemodialysis; CVVHDF, continuous veno-venous hemodiafiltration; RRT, renal replacement therapy.