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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Cancer Immunol Res. 2014 Mar 31;2(7):655–667. doi: 10.1158/2326-6066.CIR-13-0209

Figure 5. Expression of pro-tumorigenic genes by TANs.

Figure 5

A, Comparison of gene expression profiles of TANs and Gr1hi MDSCs from 4T1 tumor-bearing mice to naive neutrophils (left, fold-change vs fold-change, 2-fold change). Expression of these probes was further analyzed in fold-change vs fold-change plots comparing TANs from B16 and Her2 tumors to naive neutrophils (right). 170 of the 214 probes passed the CV<0.5 filter. B, Heatmap showing the expression of the 170 probes identified in A across neutrophils. C, Top 20 canonical pathways enriched for TANs and Gr1hi MDSCs compared to naive neutrophils analyzed by Ingenuity Pathway Analysis.