Table 1.
Results from simulated cohort data: Nested case-control study based on actual cohort failures (disease), empirical evaluation according to DRL method and the corresponding cohort analyses. For the simulated data there was no association between exposure and disease, but exposure was associated with time of entry.
| Disease as outcome | Nested case-control study | Cohort/ failures are diseased subjects | |||||
|---|---|---|---|---|---|---|---|
| Cases | Controls | Rate ratio | CI | Population | Rate ratio | CI | |
| Unexposed | 271 | 1312 | 1 | -- | 2499 | 1 | -- |
| Exposed | 205 | 1068 | 0.93 | (0.76-1.13) | 2501 | 0.90 | (0.75-1.09) |
| Empirical evaluation | Sampled proband nested case-control study | Cohort/ failures are all subjects | |||||
|---|---|---|---|---|---|---|---|
| Cases | Controls | Rate ratio | CI | Population | Rate ratio | CI | |
| Unexposed | 226 | 1568 | 1 | -- | 2499 | 1 | -- |
| Exposed | 250 | 809 | 2.29 | (1.89-2.82) | 2501 | 2.32 | (2.19-2.46) |