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. 2014 May 13;33(13):1438–1453. doi: 10.15252/embj.201386907

Figure 4. Lifespan extension of BubR1H/H mice by SIRT2 overexpression.

Figure 4

A Lifespan of BubR1H/H (n = 31) and SIRT2tg/BubR1H/H (n = 33) mice. P = 0.0384 determined by log-rank test.

B Lifespan of males BubR1H/H (NT, n = 16) and SIRT2tg/BubR1H/H (SIRT2tg, n = 17) mice, P = 0.004.

C Lifespan of females BubR1H/H (NT, n = 15) and SIRT2tg/BubR1H/H (SIRT2tg, n = 16) mice, N.S. (P = 0.7915).

D–F Lysates from testes (D), spleen (E), and hearts (F) isolated from wild-type, BubR1H/H, and SIRT2tg/BubR1H/H mice were Western blotted for BubR1, SIRT2, and tubulin.