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. 2014 May 13;33(13):1438–1453. doi: 10.15252/embj.201386907

Figure 5. Reversal of cardiac defects in BubR1H/H mice by SIRT2.

Figure 5

  1. Hearts from male 3-month-old wild-type (n = 6), BubR1H/H (n = 5), and SIRT2tg/BubR1H/H (n = 6) mice were weighed and normalized to tibia length.
  2. Kidneys analyzed as in (A).
  3. LVID;d measured by echocardiography.
  4. Left ventricle mass calculated with echocardiography measurements.
  5. Representative ECG tracings from 3-month-old wild-type, BubR1H/H, and SIRT2tg/BubR1H/H mice with inset highlighting J-point. Electrocardiography measurements from male 3-month-old wild-type (n = 12), BubR1H/H (n = 14), and SIRT2tg/BubR1H/H (n = 12) mice representing (F) J-point amplitudes and (G) normalization of J-point to R-wave amplitude.

Data information: Error bars represent SEM. P-values calculated using Student’s t-test (n as specified), *P < 0.05, **P < 0.005.