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. 2014 May 13;33(13):1438–1453. doi: 10.15252/embj.201386907

Figure 7. Models for the regulation of BubR1 by SIRT2 and its relevance to age-related decline.

Figure 7

  1. Model for regulation of BubR1 stability by reversible acetylation mediated by CBP and SIRT2.
  2. Working model for the stabilization of BubR1 protein abundance by SIRT2 during aging and the effects of increasing NAD+ levels.