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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Microcirculation. 2014 Oct;21(7):640–648. doi: 10.1111/micc.12143

Figure 1.

Figure 1

Effect of combined pharmacological blockade of nitric oxide and histamine production on flow-dependent relaxation of mesenteric lymphatic vessels.

A – lymphatic tone index; B – contraction amplitude; C- contraction frequency; D – fractional pump flow.

Control – control MLVs after overnight culture;

L-NAME – same control vessels after subsequent acute pharmacological blockade of NO production by the nitric oxide synthase non-specific blocker, L-NAME (100 μM);

a-MHD – MLVs after overnight pharmacological blockade of histamine production by HDC specific blocker, α-MHD in 10 μM;

a-MHD + L-NAME – same α-MHD-treated vessels after subsequent acute pharmacological blockade of NO production by nitric oxide synthases non-specific blocker, L-NAME in 100 μM.

* indicates significant differences (P < 0.05) between lymphatic contractile parameters within each treatment group at no-flow and at any imposed flow condition.

+ indicates significant differences (P < 0.05) between lymphatic contractile parameters in any treatment groups and control within any given imposed flow condition.