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. 2014 Aug 28;234(3):375–385. doi: 10.1002/path.4403

Figure 3.

Figure 3

Non-canonical NF-κB signalling induces in vitro sprouting of endothelial cells. (A) Representative pictures of tube formation by HMVECs under basal conditions or after LT, LIGHT, and CD40L stimulation (scale bar for all panels = 500 µm). (B) Quantification of LT-, LIGHT-, and CD40L-enhanced tube formation. n = 7 per group, three independent experiments. (C–F) HMVECs were transfected by the indicated siRNAs. Scrambled non-targeting siRNA (=siC) was used as a control. (C) Basal tube formation; (D) LT-enhanced tube formation; (E) LIGHT-enhanced tube formation; (F) CD40L-enhanced tube formation. n = 6 per group, three independent experiments. All panels: mean ± SEM. *p < 0.05; **p < 0.01. Specific knockdown of the genes targeted by the siRNAs is shown in Supplementary Figure 4.