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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Respirology. 2014 Aug 19;19(8):1170–1177. doi: 10.1111/resp.12368

Figure 1. Comparison of the proportion of the fall in FEV1 during methacholine challenge that is due to airway closure prior to bariatric surgery.

Figure 1

The Closing Index, calculated as the % fall in FVC/ % fall in FEV1 at the highest dose of the methacholine challenge, was compared between obese non-asthmatic, obese asthmatics with elevated serum IgE (TH2-high) and obese asthmatics with normal serum IgE (TH2-low). A larger closing index represents a greater proportion of overall bronchoconstriction attributed to airway closure. The mean± SEM closing index in normal weight non-asthmatics is 0.54 ± 0.03 (9). ns = non-significant ANOVA.