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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Respirology. 2014 Aug 19;19(8):1170–1177. doi: 10.1111/resp.12368

Figure 4. Comparison of the sensitivity to airway narrowing (a) and airway closure (b) in obese asthmatic subjects before (pre) and 12 months following bariatric surgery (post).

Figure 4

Obese asthmatic subjects were grouped into those with elevated IgE (TH2-high) and those with normal IgE (TH2-high). Sensitivity to methacholine was measured as the dose response slope (DRS), calculated as the two point slope from the fall in lung function at the end of challenge divided by the dose of methacholine (MCh) in µmoles. The sensitivity to airway narrowing and airway closure was determined by calculating a DRS using % fall in FEV1/FVC (DRS(FEV1/FVC)) and % fall in FVC (DRSFVC). DRS is log-normally distributed and is thus plotted on a log-scale

The p-values shown are for the TH2-status × surgery interaction factor

.p = 0.79 (A) and 0.11 (B) for effect of surgery