Skip to main content
. Author manuscript; available in PMC: 2014 Dec 15.
Published in final edited form as: Cell Rep. 2014 Oct 2;9(1):9–15. doi: 10.1016/j.celrep.2014.08.075

Figure 1. TOR is required for longevity following transient hypoxia.

Figure 1

(A) Methods for transient hypoxia treatment in C. elegans fed OP50 bacteria. (B) Transient hypoxia during either development or adulthood is sufficient to extend lifespan. (C) Methods for transient hypoxia treatment in C. elegans fed HT115 dsRNA producing bacteria. On day 3 of adulthood, animals may be removed to vector control plates (transient RNAi) or maintained on dsRNA producing bacteria (continuous RNAi). (D) Transient RNAi of the C. elegans TOR homolog, LET-363, prevents lifespan extension following transient hypoxia treatment. Cox proportional hazard analysis of transient control RNAi and transient TOR RNAi under hypoxia = 1.618 (95% CI 1.311 – 1.997).