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. Author manuscript; available in PMC: 2014 Dec 15.
Published in final edited form as: Cell Rep. 2014 Oct 2;9(1):9–15. doi: 10.1016/j.celrep.2014.08.075

Figure 2. TORC1 and ROS are necessary for transient hypoxia extension of lifespan.

Figure 2

(A) Transient RNAi of the TORC1 activator, RHEB-1, prevents longevity following transient hypoxia treatment. (B) Transient RNAi of the TORC1 scaffold protein RAPTOR prevents adaptation to hypoxia. (C) Transient hypoxia does not increase autophagy in the C. elegans nhx-2::LGG-1::RFP reporter strain, suggesting TORC1 is not inhibited under hypoxia (* = p < 0.05, NS = not significant). (D) Methods for BHA treatment in C. elegans. (E) The antioxidant BHA suppresses longevity following transient hypoxia compared to ethanol (ETOH) control.