. Author manuscript; available in PMC: 2015 Oct 1.

Published in final edited form as: Transfusion. 2014 Sep 4;54(10):2365–2371. doi: 10.1111/trf.12848

Table 1.

RBC Clearance: Types and Examples

Clearance Type	Examples
Sequestration
	Hypersplenism
	Sickle Cell Anemia
	Cerebral Malaria
	Autoagglutination
Fragmentation
	Disseminated Intravascular Coagulation
	Thrombotic Thrombocytopenic Purpura
	Prosthetic heart valves
	Pyropoikylocytosis
Intravascular Lysis^*
	IgM-mediated Acute Hemolytic Transfusion Reaction
	“Cold-type” Autoimmune Hemolytic Anemia
	Paroxysmal Cold Hemoglobinuria
	Paroxysmal Nocturnal Hemoglobinuria
	Black Recluse Spider Venom
Phagocytosis^†
	IgG-mediated Delayed Hemolytic Transfusion Reaction
	“Warm-type” Autoimmune Hemolytic Anemia
	Oxidative Damage (e.g., Glucose-6-phosphate Dehydrogenase Deficiency)
	Hemophagocytic Lymphohistiocytosis
	Physiological RBC Senescence

Also termed “intravascular hemolysis.”

^†

Also termed “extravascular hemolysis.”