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T-dCyd and aza-T-dCyd induce DNMT1 depletion in leukemia cells and in solid tumor cells. Exponentially growing leukemia cells (a CCRF-CEM, upper panel and KG1a, lower panel) or solid tumor cells (b NCI-H23 lung carcinoma, HCT-116 colon carcinoma or IGROV-1 ovarian carcinoma cells) were exposed to indicated concentrations of either T-dCyd or aza-T-dCyd for 96 h. Cell lysates were fractionated on SDS-PAGE gels and were analyzed by Western blotting using antibodies against DNMT1 or GAPDH
