. Author manuscript; available in PMC: 2014 Oct 12.

Published in final edited form as: J Pharm Sci. 2011 Oct 11;101(2):616–626. doi: 10.1002/jps.22791

Table III.

Donor concentrations and flux of THC, THC-HS and THC-HG (in terms of total THC) and WIN in different vehicles at 34 °C across isolated rabbit cornea. Results are depicted as mean ± SD (n=3).

Drug	Donor pH	Donor Vehicle	Donor Concentration (µg/mL)	Flux (µg/cm²/min × 10⁻²)	Predicted Maximum Flux^* (µg/cm²/min × 10⁻²)
THC	5	2.5 % HPβCD in DPBS	40.7 ± 0.7	1.7 ± 0.2	-
	7.4	2.5 % HPβCD in DPBS	46.8 ± 2.9	1.6 ± 0.1	-
	7.4	30 % HPβCD in DPBS	40.1 ± 0.7	No drug detected	-
	7.4	2.5 % RMβCD in DPBS	19.9 ± 0.9	1.5 ± 0.2	-
WIN	5	2.5 % HPβCD in DPBS	73.3 ± 2.8	5.4 ± 0.3	-
	7.4	2.5 % HPβCD in DPBS	86.3 ± 12.4	5.7 ± 0.6	-
	7.4	30 % HPβCD in DPBS	97.2 ± 0.4	0.8 ± 0.1	-
	7.4	2.5 % RMβCD in DPBS	238.3 ± 17.5	13.2 ± 0.6	-
THC-HS	5	2.5 % HPβCD in DPBS	64.3 ± 4.3	14.9 ± 0.9	-
	6	2.5 % HPβCD in DPBS	29.8 ± 2.9	1.5 ± 0.1	-
	7.4	2.5 % HPβCD in DPBS	73.1 ± 0.7	0.9 ± 0.5	5.1 ± 3.7
	7.4	2.5 % RMβCD in DPBS	103.5 ± 12.9	3.5 ± 0.1	14.7 ± 0.5
THC-HG	5	2.5 % HPβCD in DPBS	53.8 ± 3.1	11.4 ± 1.1	-
	6	2.5 % HPβCD in DPBS	30.1 ± 1.5	1.7 ± 0.2	-
	7.4	2.5 % HPβCD in DPBS	30.9 ± 1.9	0.3 ± 0.1	6.5 ± 2.1
	7.4	2.5 % RMβCD in DPBS	30.1 ± 0.4	1.9 ± 0.2	56.3 ± 6.1
	7.6	2 mM l-arginine in IPBS	78.9 ± 8.1	14.9 ± 0.9	79.9 ± 11.9
	7.6	2 mM l-arginine + BCH in IPBS	71.6 ± 6.5	13.4 + 0.9	-
	7.6	2 mM Tromethamine in IPBS	71.9 ± 2.2	17.1 ± 2.6	51.9 ± 9.1

Maximum flux values were calculated theoretically by multiplying observed permeability with maximum solubility values depicted in Table I and Table II. Maximum values have not been presented for formulations wherein maximum solubility was not calculated.