Appendix Table 2.
ACMPE full model results [parameter estimate (standard error)]
| Within SDP |
Within outcome |
Between phenotypes |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| as | cs | ms | ps | es | ao | co | mo | po | eo | rA | rC | rM | rP | rE | |
| Birth weight | 0.823 (0.003) | 0.262 (0.003) | 0.213 (0.003) | 0.354 (0.003) | 0.288 | 0.394 (0.003) | 0.207 (0.003) | 0.147 (0.001) | 0.035 (0.003) | 0.300 (0.003) | −0.046 (0.003) | −0.773 (0.001) | −0.679 (0.003) | −1.000 (0.005) | −0.244 (0.001) |
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| Preterm birtha | 0.828 (0.008) | 0.183 (0.015) | 0.202 (0.017) | 0.394 (0.003) | 0.290 | 0.514 (0.048) | 0.494 (0.019) | 0.277 (0.015) | 0.002 (0.075) | 0.644 | NA | NA | NA | NA | NA |
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| Born small for gestational agea | 0.828 (0.008) | 0.183 (0.015) | 0.202 (0.017) | 0.394 (0.003) | 0.290 | 0.660 (0.015) | 0.396 (0.015) | 0.270 (0.011) | 0.002 (0.075) | 0.578 | NA | NA | NA | NA | NA |
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| Low academic achievement | 0.810 (0.000) | 0.344 (0.000) | 0.267 (0.000) | 0.296 (0.000) | 0.258 | 0.893 (0.000) | 0.154 (0.000) | 0.366 (0.000) | 0.105 (0.000) | 0.185 | 0.598 (0.001) | 0.024 (0.006) | 0.623 (0.001) | 0.494 (0.009) | −0.018 (0.001) |
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| General cognitive ability | 0.813 (0.022) | 0.263 (0.020) | 0.307 (0.019) | 0.313 (0.016) | 0.278 | 1.076 (0.033) | 0.819 (0.023) | 0.097 (0.019) | 0.212 (0.012) | 1.244 (0.016) | −0.536 (0.010) | −0.071 (0.014) | −0.327 (0.008) | −0.980 (0.010) | −0.030 (0.010) |
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| Criminality | 0.802 (0.029) | 0.351 (0.030) | 0.290 (0.038) | 0.291 (0.011) | 0.254 | 0.573 (0.024) | 0.203 (0.024) | 0.222 (0.018) | 0.076 (0.030) | 0.759 | 1.000 (0.099) | −0.693 (0.090) | 0.009 (0.120) | 0.511 (0.498) | 0.000 (0.016) |
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| Violent criminality | 0.782 (0.017) | 0.370 (0.020) | 0.314 (0.019) | 0.297 (0.012) | 0.255 | 0.795 (0.061) | 0.000 (0.155) | 0.272 (0.042) | 0.057 (0.073) | 0.538 | 0.654 (0.228) | 0.795 (0.147) | 0.421 (0.481) | 0.522 (0.816) | 0.024 (0.039) |
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| Drug misuse | 0.835 (0.001) | 0.293 (0.001) | 0.260 (0.001) | 0.296 (0.001) | 0.250 | 0.600 (0.001) | 0.256 (0.001) | 0.146 (0.000) | 0.088 (0.000) | 0.738 | 0.591 (0.001) | 0.190 (0.000) | 0.743 (0.001) | 0.182 (0.000) | 0.000 (0.000) |
Abbreviations: SDP, maternal smoking during pregnancy. NA, not applicable.
Note: Standard errors may be misleading due to constraints put on the optimizer when fitting the model. The e-parameters for binary phenotypes are defined as remaining variance after estimation of other parameters and are therefore void of standard errors.
Due to computational issues SDP and outcome were fitted separately.