Table 3.
[11C]NNC112 BPF by Diagnostic Group for PFCa and Striatal ROIs
| ROI | Controls (n=20b) | SPD (n=18) | pc |
|---|---|---|---|
| PFC: | |||
| DLPFC | 357.61 ± 109.66 | 408.58 ± 187.08 | 0.306 |
| MPFC | 373.28 ± 129.22 | 414.40 ± 179.27d | 0.466 |
| OFC | 377.23 ± 160.76 | 447.50 ± 207.56 | 0.248 |
|
| |||
| Striatal: | |||
| VST | 663.41 ± 219.96 | 877.40 ± 335.61 | 0.025 |
| preDCA | 762.28 ± 237.42 | 928.88 ± 359.64 | 0.097 |
| preDPU | 813.18 ± 266.70 | 990.80 ± 380.12 | 0.101 |
| postCA | 584.59 ± 196.56 | 698.07 ± 309.58 | 0.181 |
| postPU | 781.91 ± 265.39 | 939.80 ± 363.83 | 0.132 |
| whole STR | 755.49 ± 241.89 | 927.82 ± 358.57 | 0.088 |
Note. Mean ± Standard Deviation (observed).
STR=striatum; see Table 2 for other abbreviations.
a
BPF values for all PFC (but not striatal) ROIs were adjusted to correct for partial volume effects (PVE); see text.
b
n=20: BPF values were missing for one control due to unavailability of fp term.
c
Group comparisons of the estimated marginal means derived from linear mixed modeling (see text) with the exception of the composite whole STR; for this region, an independent-samples t-test was used.
d
n=17: One SPD participant’s values were excluded due to excessive noise in the VT measurement.