Table 4.

[¹¹C]NNC112 BP_ND by Diagnostic Group for PFC^a and Striatal ROIs

ROI	Controls (n=21)	SPD (n=18)	pb
PFC:
DLPFC	1.35 ± 0.22	1.28 ± 0.27	0.369
MPFC	1.40 ± 0.24	1.28 ± 0.25c	0.172
OFC	1.40 ± 0.34	1.39 ± 0.30	0.960
Striatal:
VST	2.50 ± 0.49	2.78 ± 0.44	0.064
preDCA	2.90 ± 0.59	2.94 ± 0.45	0.792
preDPU	3.08 ± 0.65	3.14 ± 0.53	0.772
postCA	2.19 ± 0.41	2.20 ± 0.48	0.969
postPU	2.96 ± 0.60	2.98 ± 0.50	0.885
whole STR	2.86 ± 0.54	2.94 ± 0.46	0.618

Note. Mean ± Standard Deviation (observed).

STR=striatum; see Table 2 for other abbreviations.

^aBP_ND values for all PFC (but not striatal) ROIs were adjusted to correct for partial volume effects (PVE); see text.

^bGroup comparisons of the estimated marginal means derived from linear mixed modeling (see text) with the exception of the composite whole STR; for this region, an independent-samples t-test was used.

^cn=17: One SPD participant’s values were excluded due to excessive noise in the V_T measurement.