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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Exp Neurol. 2014 May 20;0:328–336. doi: 10.1016/j.expneurol.2014.05.014

Figure 4.

Figure 4

Bath application of CXCL1 increases NMDA-induced currents in lamina IIo neurons in spinal cord slices. (A) Patch-clamp recording demonstrates increase in NMDA-induced currents after CXCL1 treatment (100 ng/ml, 2 min), which is blocked by SB225002 (0.1 μM). (B) Histogram shows the amplitude of NMDA-induced currents. * P < 0.05 compared to NMDA alone. # P < 0.05, compared to NMDA + CXCL1 treatment. n = 4–7 neurons/group. (C) Patch-clamp recording shows CXCL1 increases NMDA-induced current in naïve and CFA-treated animals. (D) Histogram shows the NMDA-induced inward current. * P < 0.05 compared to naïve. (E) Histogram shows the increased magnitude of NMDA-induced currents. * P < 0.05 compared to pretreatment baseline. # P < 0.05, CFA 3 days compared to naïve. n = 5–7 neurons/group.