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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Exp Neurol. 2014 May 20;0:328–336. doi: 10.1016/j.expneurol.2014.05.014

Figure 5.

Figure 5

CXCL1 increases the expression of COX-2 in spinal cord neurons. (A–C) Intrathecal injection of CXCL1 (100 ng) increases COX-2 expression at 2 h after injection. (D) Majority of COX-2 immunoreactive cells in spinal cord express the neuronal marker NeuN. (E) CXCL1 also increased COX-2 mRNA expression in the spinal cord, which is blocked by pretreatment with SB225002 (20 μg) or PD98059. * P < 0.05, ** P < 0.01 compared to PBS. # P < 0.05 compared to CXCL1, one-way ANOVA followed by Newman-Keuls post hoc test. n = 4 mice/group.