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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: J Biomed Inform. 2014 Apr 13;0:24–34. doi: 10.1016/j.jbi.2014.03.016

Table 3.

The actionable measurement gap separation method for finding and removing a confounding bias in laboratory test EHR data.

Measurement Gap Separation Method
Step Action Motivation

1 Plot a histogram of the frequency and measurement gap in log-log coordinates. The histogram provides a method to visually examine the laboratory tests measurement dynamics.

2 Examine the modality of the plot; looking for multi-modality. If the histogram is multi-modal, it may imply a difference in patient health states or a healthcare process bias.

3 If there are multiple peaks, define a measurement gap threshold to separate the peaks. This separation defines multiple settings for the EHR experiment, creating sets of homogenous data points with respect to their measurement gaps.

4 Perform the EHR experiment separately for each setting. Separately performing experiments for different settings may remove confounding bias.