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Schematic representation of LRRK2. The central region of LRRK2 contains a GTPase domain also called ROC, a COR domain of unknown function and a kinase domain, flanked on either side by multiple protein–protein interaction domains: WD40 domain; ANK, ankyrin repeat domain and LRR, leucine-rich repeats. PD pathogenic mutations are depicted in red on top and phosphorylation sites are depicted in blue below. The scale of each domain or protein is not proportional to its actual size.
