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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Exp Neurol. 2014 Jun 4;0:206–216. doi: 10.1016/j.expneurol.2014.05.025

Figure 2.

Figure 2

LRRK2 involvement in cellular mechanisms. Several data posit that LRRK2 through its kinase and/or GTPase domain can affect mitochondrial function, ubiquitin-proteasome system, autophagy-lysosomal pathway, microtubule dynamics as well as trafficking of vesicles and proteins, alpha-synuclein phosphorylation content and immune system cells.