Skip to main content
. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Exp Neurol. 2014 Aug 8;0:553–562. doi: 10.1016/j.expneurol.2014.08.001

Fig. 5.

Fig. 5

Response of EA2 mutant mice to caffeine and EtOH. (A) Rotarod performance was assessed following 15 mg/kg caffeine or saline in +/+ (n=14), EA2/+ (n=11), EA2/EA2 (n=11), and EA2/− (n=6) mice previously trained on rotarod. No main effect of caffeine (F1,38=0.24, P>0.5) or interaction between genotype and caffeine (F3,38=0.82, P>0.4) were found. (B) Rotarod performance was assessed 20 minutes following EtOH (1,1.5, and 2g/kg) in the same cohort of mice. A significant effect of genotype (F3,38=4.73, P<0.01, *p<0.05 for EA2/-) and EtOH dose was found (F3,114=167, P<0.001, *p<0.05 for 1g/kg, ***p<0.001 for 1.5g/kg and 2g/kg), but no interaction was found between EtOH and genotype (F9,114=0.66, P>0.5).