Inactivation of G9a activity before ethanol treatment at P7 prevents
object recognition memory loss in adult mice. (A) Level of exploration was
measured at el and e2, respectively: the time spent exploring the two objects in
T1 and T2 (at 1+4 and 24 h) by S+V, E+V, S+ Bix, and E+ Bix-treated mice. (B)
Discrimination indices (d2) obtained from the S+V, E+V, S+ Bix, and E+
Bix-treated mice after 1and 4 h retention intervals. (C) Discrimination indices
(d2) obtained from the S+V, E+V, S+ Bix, and E+ Bix-treated mice after 24 h
retention intervals. Each point is the mean + SEM (n= 8 mice/group). One-way
ANOVA with Bonferroni’s post hoc test; ***p <
0.001 vs. S + V; #p < 0.001 vs. E + V .