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. Author manuscript; available in PMC: 2015 Dec 15.
Published in final edited form as: Biol Psychiatry. 2014 Apr 12;76(12):953–962. doi: 10.1016/j.biopsych.2014.04.003

Figure 5. SNAP-25 participates in the potentiation of NMDAR-EPSC and cognitive functions by low-dose MPH.

Figure 5

(A) Summarized input-output curves of NMDAR-EPSC in saline- vs. MPH- (0.5 mg/kg, i.p.) injected rats pre-treated with SNAP-25 blocking peptide (SNAP-25 pep, 0.6 pmol/g, i.v.) or a scrambled peptide (sc pep, 0.6 pmol/g, i.v.). Inset: representative EPSC traces. Scale bar: 50 pA, 200 ms. *: p < 0.05. (B, C) Immunoblots (B) and quantification analysis (C) of the surface and total NMDAR subunits in rat PFC slices from saline- vs. MPH-injected rats pre-treated with SNAP-25 blocking peptide or a scrambled peptide. **: p < 0.01. (D, E) Bar graphs showing the discrimination ratio (DR) of temporal order recognition memory (TORM) tasks (D) or number of trials to criterion at each discrimination stage of the attentional set-shifting task (E) in MPH (0.5 mg/kg, i.p.)-injected animals pre-treated with a scrambled peptide or SNAP-25 blocking peptide. *: p < 0.05.