Fig. 5.

The LRRK2 kinase inhibitor H-1152 did not affect motor activity in mice carrying a LRRK2 mutation (D1994S) that silences kinase activity (kinase dead; D1994S KD). Time-course of the motor effects of H-1152 (1 mg/kg, i.p.) in 12-month-old D1994S KD mice and wild-type littermates (WT), assessed using the bar (A), drag (B) and rotarod (C) tests, before (time 0; basal values) and after (30, 120, 360 min, 24 h) drug administration. Data are means ± SEM of 6 mice per group, and were analyzed using one-way RM ANOVA followed by the Newman–Keuls test for multiple comparisons.