Table 1.
G2019S LRRK2 knock-in (KI) mice weighed less than wild-type littermates (WT) throughout the study. No difference was observed between D1994S LRRK2 kinase-dead (D1994S KD) and respective WT littermates. Data are expressed in grams and are means ± SEM of the number of mice indicated in parentheses.
*P < 0.05, **P < 0.01 different from WT (2-way ANOVA followed by the Bonferroni post hoc test).
| Age (months) |
|||||
|---|---|---|---|---|---|
| Genotype | 3 | 6 | 9 | 15 | 19 |
| G2019S KI (g) | 23.8 ± 0.9** (11) | 27.5 ± 0.4** (11) | 30.4 ± 0.4** (11) | 30.9 ± 0.4** (11) | 31.8 ± 0.4* (6) |
| WT (g) | 28.8 ± 0.8 (9) | 31.5 ± 0.8 (9) | 34.7 ± 0.8 (9) | 35.3 ± 1.2 (9) | 36.2 ± 1.4 (6) |
| D1994S KD (g) | 25.6 ± 0.4 (10) | nt | 32.0 ± 0.6 (10) | 33.1 ± 0.7 (10) | nt |
| WT (g) | 26.0 ± 0.4 (9) | nt | 33.4 ± 0.7 (9) | 34.6 ± 0.7 (9) | nt |
nt = not tested.