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. 2004 Apr 30;32(8):2396–2410. doi: 10.1093/nar/gkh527

Figure 7.

Figure 7

Inhibition of c-myc promoter activity is dependent on the triplex-forming ability of daunomycin-conjugated TFO. (A) Structure of the daunomycin-conjugated control oligonucleotide dauno-GT11C. (B) Gel mobility shift assay with duplex DNA incubated without (control) or with dauno-GT11 (D-GT11), dauno-GT11C (D-GT11C) or non-conjugated GT11. (C) DU145 cells were transfected with p262-Myc reporter plasmid and pRL control vector in the presence of 1 µM of dauno-GT11 (empty bars), dauno-CO11 (filled bars) or dauno-GT11C (gray bars). Luciferase activity was measured as described in the legend to Figure 6.