Table 2.

Pros and cons for prescribing auto-injectable epinephrine for SLIT

Pros	Cons
● There is a slight, though rare risk for anaphylaxis.	● Adverse reactions with SLIT are generally mild, and systemic reactions are generally not severe, with no deaths reported.
● SLIT is a home-based therapy without anaphylaxis-trained practitioners available should a reaction occur	● Auto-injectable epinephrine may be used incorrectly or inappropriately by patients.
● There are medical-legal concerns if a patient should have a reaction at home without having an auto-injector prescribed.	● Auto-injectors are not required for SLIT in Europe and Canada. Many US practitioners do not require them for SCIT patients.
	● Costs of epinephrine autoinjectors