Table 2.
Predictors of one year of follow-up virological and immunological failure by univariate logistic regression
| Virological failure | Immunological failure | |||||
|---|---|---|---|---|---|---|
| > 400 copies/ml | > 1,000 copies/ml | |||||
| Predictor | OR (95% CI) | p-value | OR (95% CI) | p-value | OR ( 95% CI) | p-value |
| Age per 1 year older | 1 (0.96 - 1.03) | 0.8 | 0.97 (0.93 - 1.02) | 0.24 | 0.92 (0.85 - 0.98) | 0.02 |
| Being able to recall diagnosis date | 0.39 (0.2 - 0.75) | 0.01 | 0.3 (0.14 - 0.63) | <0.01 | 0.31(0.1 - 0.87) | 0.03 |
| Being on nevirapine regimen | 2.17 (1.06 - 4.64) | 0.04 | 2.76 (1.18 - 7.28) | 0.03 | 1.3 (0.46 - 4.28) | 0.64 |
| Being on efavirenz regimen | 0.48 (0.22 - 0.98) | 0.05 | 0.37 (0.14 - 0.88) | 0.03 | 0.79 (0.24 - 2.27) | 0.68 |
| Being on stavudine regimen | 1.99 (1.03 - 3.89) | 0.04 | 2.23 (1.06 - 4.83) | 0.04 | 1.71 (0.62 - 4.94) | 0.3 |
| Body mass index per unit | 1.06 (1.01 - 1.12) | 0.03 | 1.02 (0.96 - 1.07) | 0.53 | 0.97 (0.87 - 1.05) | 0.5 |
| Weight per 1 kg higher | 1.03 (1 - 1.06) | 0.03 | 1.02 (0.99 - 1.05) | 0.13 | 0.99 (0.95 - 1.03) | 0.65 |
| Having baseline CD4 T lymphocytes count < 200 cell/μl | 1.47 (0.7 - 3.03) | 0.3 | 2.9 (1.32 - 6.35) | 0.01 | 2.9 (1.02 - 8.17) | 0.04 |
| Therapy duration | 8.67 (1.47 - 66.9) | 0.02 | 8.75 (1.35 - 80.87) | 0.03 | 2 (0.2 - 19.79) | 0.53 |
| Being on triomune regimen | 2.07 (1.07 - 4.04) | 0.03 | 2.31 (1.1 - 5) | 0.03 | 1.76 (0.64 - 5.08) | 0.28 |
| Undetectable viral load at baseline | 0.46 (0.21 - 1.01) | 0.05 | 0.29 (0.13 - 0.68) | <0.01 | 0.23 (0.08 - 0.68) | 0.01 |
| Ever having drug holidays | 3.32 (1.06 - 11.29) | 0.04 | 5.2 (1.56 - 18.4) | 0.01 | 2.46 (0.54 - 10.72) | 0.23 |
| SHCS-AQ adherence | 0.83 (0.41 - 1.72) | 0.61 | 0.78 (0.36 - 1.76) | 0.54 | 0.7 (0.25 - 2.14) | 0.51 |
| VAS adherence (>95%) | 0.65 (0.25 - 1.68) | 0.36 | 0.54 (0.2 - 1.53) | 0.22 | 0.21 (0.07 - 0.69) | 0.01 |
| Appointment adherence >80%) | 0.68 (0.31 - 1.5) | 0.33 | 0.65 (0.28 - 1.57) | 0.32 | 1.28 (0.39 - 5.8) | 0.71 |
| Pharmacy refill adherence (>95%) | 0.41 (0.21 - 0.8) | 0.01 | 0.26 (0.12 - 0.57) | <0.01 | 1.23 (0.45 - 3.55) | 0.69 |
| Pill count adherence (>90%) | 1.86 (0.62 - 5.5) | 0.26 | 1.9 (0.56 - 5.78) | 0.27 | 0.66 (0.04 - 3.7) | 0.7 |
Key: SHCS-AQ = Swiss HIV Cohort study Adherence questionnaire; VAS = Visual analog scale; OR = odds ratio; CI = confidence interval.