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. 2014 Oct 14;20(38):13741–13755. doi: 10.3748/wjg.v20.i38.13741

Figure 1.

Figure 1

Human epidermal growth factor receptor 2 signaling pathways. HER: Human epidermal growth factor receptor; BAD: Bcl-2-associated death promotor protein; Grb2: Growth factor receptor-bound protein 2; MAPK: Mitogen-activated protein kinase; MEK: Mitogen-activated protein kinase kinase 1; NF-κB: Nuclear factor κB; PI3K: Phospohoinositide 3-kinase; PKC: Protein kinase C; PLC-γ: Phospholipase C gamma 1; SOS: Son of sevenless; mTOR: Mammalian target of rapamycin; RAS: Rat sarcoma viral oncogene; RAF: Rapidly accelerated fibrosarcoma.