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. 2014 Oct 14;20(38):13741–13755. doi: 10.3748/wjg.v20.i38.13741

Figure 3.

Figure 3

Epidermal growth factors signaling pathways. Activation of EGFR leads to downstream signaling pathways that ultimately drive tumour proliferation or impair apoptosis. JAK: Janus kinase; STAT: Signal transduction and activator of transcrption; ERK: Extracellular signal-regulated kinase; PI3K: Phospohoinositide 3-kinase; PKC: Protein kinase C; PLC: Phospholipase C; SOS: Son of sevenless; mTOR: Mammalian target of rapamycin; RAS: Rat sarcoma viral oncogene; RAF: Rapidly accelerated fibrosarcoma; EGFR: Epidermal growth factor receptor.