Table 4.
Comparison of diagnostic performance between noninvasive serum marker for discriminating F0-1 vs F2-4 (significant fibrosis), F0-2 vs F3-4 (advanced fibrosis) and F0-3 vs F4 (cirrhosis) (n =61)
| AUROC | 95%CI |
Pairwise comparison of ROC curves |
|||
| Factor | Difference between areas (95%CI) | P value | |||
| Significant fibrosis | |||||
| SWE | 0.908 | 0.806-0.967 | HA | 0.097 (-0.012-0.205) | 0.081 |
| Type IV | 0.067 (-0.003-0.167) | 0.189 | |||
| APRI | 0.217 (0.074-0.359) | 0.003 | |||
| HA | 0.812 | 0.691-0.900 | Type IV | 0.030 (-0.092-0.152) | 0.634 |
| APRI | 0.120 (-0.041-0.281) | 0.145 | |||
| Type IV | 0.841 | 0.725-0.922 | APRI | 0.150 (-0.006-0.305) | 0.059 |
| APRI | 0.691 | 0.560-0.803 | |||
| Advanced fibrosis | |||||
| SWE | 0.893 | 0.787-0.957 | HA | 0.004 (-0.093-0.101) | 0.939 |
| Type IV | 0.017 (-0.080-0.113) | 0.735 | |||
| APRI | 0.150 (0.013-0.287) | 0.032 | |||
| HA | 0.897 | 0.792-0.960 | Type IV | 0.020 (-0.074-0.115) | 0.671 |
| APRI | 0.154 (0.014-0.293) | 0.031 | |||
| Type IV | 0.876 | 0.767-0.947 | APRI | 0.133 (-0.010-0.277) | 0.069 |
| APRI | 0.743 | 0.615-0.846 | |||
| Cirrhosis | |||||
| SWE | 0.877 | 0.768-0.947 | HA | 0.002 (-0.114-0.118) | 0.974 |
| Type IV | 0.027 (-0.084-0.138) | 0.631 | |||
| APRI | 0.194 (0.031-0.358) | 0.002 | |||
| HA | 0.879 | 0.770-0.948 | Type IV | 0.029 (-0.072-0.130) | 0.571 |
| APRI | 0.196 (0.022-0.371) | 0.027 | |||
| Type IV | 0.850 | 0.736-0.928 | APRI | 0.167 (-0.003-0.338) | 0.055 |
| APRI | 0.683 | 0.551-0.796 | |||
ROC: Receiver-operating characteristic curves; AUROC: Area under the ROC curve; SWE: Shear wave elastography; HA: Hyaluronic acid; Type IV: Type IV collagen; APRI: Aspartate aminotransferase to platelet ratio index.