Table 5.
Comparison of diagnostic performance between shear wave elastography and noninvasive serum markers for discriminating F0-1 vs F2-4 (significant fibrosis) and F0-2 vs F3-4 (advanced fibrosis) in patients with chronic viral hepatitis (n =36)
| AUROC | 95%CI |
Pairwise comparison of ROC curves |
|||
| Factor | Difference between areas (95%CI) | P value | |||
| Significant fibrosis | |||||
| SWE | 0.935 | 0.800-0.989 | HA | 0.277 (0.070-0.485) | 0.009 |
| Type IV | 0.158 (-0.009-0.325) | 0.063 | |||
| APRI | 0.077 (-0.066-0.220) | 0.289 | |||
| HA | 0.658 | 0.482-0.807 | Type IV | 0.119 (-0.084-0.326) | 0.257 |
| APRI | 0.200 (-0.029-0.429) | 0.086 | |||
| Type IV | 0.777 | 0.608-0.898 | APRI | 0.081 (-0.126-0.288) | 0.445 |
| APRI | 0.858 | 0.701-0.951 | |||
| Advanced fibrosis | |||||
| SWE | 0.914 | 0.771-0.980 | HA | 0.094 (-0.054-0.243) | 0.214 |
| Type IV | 0.120 (-0.030-0.271) | 0.118 | |||
| APRI | 0.086 (-0.061-0.234) | 0.250 | |||
| HA | 0.819 | 0.656-0.927 | Type IV | 0.026 (-0.120-0.172) | 0.725 |
| APRI | 0.008 (-0.168-0.183) | 0.931 | |||
| Type IV | 0.793 | 0.626-0.909 | APRI | 0.034 (-0.153-0.221) | 0.722 |
| APRI | 0.827 | 0.665-0.932 | |||
ROC: Receiver-operating characteristic curves; AUROC: Area under the ROC curve; SWE: Shear wave elastography; HA: Hyaluronic acid; Type IV: Type IV collagen; APRI: Aspartate aminotransferase to platelet ratio index.