Table 6.
Comparison of diagnostic performance between shear wave elastography and noninvasive serum markers for discriminating F0-1 vs F2-4 (significant fibrosis) and F0-2 vs F3-4 (advanced fibrosis) with non-viral chronic liver diseases (n = 25)
| AUROC | 95%CI |
Pairwise comparison of ROC curves |
|||
| Factor | Difference between areas (95%CI) | P value | |||
| Significant fibrosis | |||||
| SWE | 0.979 | 0.826-0.988 | HA | 0.035 (-0.058-0.128) | 0.465 |
| Type IV | 0.035 (-0.051-0.121) | 0.429 | |||
| APRI | 0.389 (0.163-0.615) | 0.001 | |||
| HA | 0.944 | 0.773-0.993 | Type IV | 0.000 (-0.103-0.103) | 1.000 |
| APRI | 0.354 (0.137-0.572) | 0.001 | |||
| Type IV | 0.944 | 0.773-0.993 | APRI | 0.354 (0.130-0.578) | 0.002 |
| APRI | 0.590 | 0.378-0.781 | |||
| Advanced fibrosis | |||||
| SWE | 0.910 | 0.726-0.985 | HA | 0.077 (-0.042-0.196) | 0.206 |
| Type IV | 0.090 (-0.034-0.214) | 0.156 | |||
| APRI | 0.295 (0.060-0.530) | 0.014 | |||
| HA | 0.987 | 0.839-1.000 | Type IV | 0.013 (-0.034-0.060) | 0.593 |
| APRI | 0.372 (0.155-0.589) | 0.001 | |||
| Type IV | 1.000 | 0.862-1.000 | APRI | 0.385 (0.160-0.609) | 0.001 |
| APRI | 0.615 | 0.401-0.801 | |||
ROC: Receiver-operating characteristic curves; AUROC: Area under the ROC curve; SWE: Shear wave elastography; HA: Hyaluronic acid; Type IV: Type IV collagen; APRI: Aspartate aminotransferase to platelet ratio index.