Table 3.
Methylation of pooled genes for the diagnosis of colorectal adenomas
| Wnt pathway | DNA damage repair pathway | Other pathways | SE(95%CI) | SP(95%CI) | DOR(95%CI) | AUC |
| Wnt pathway | DNA damage repair pathway | Other pathways | 51% (47%-54%) | 92% (90%-93%) | 12.61 (8.66-18.37) | 0.883 |
| Wnt pathway | - | - | 40% (35%-46%) | 95% (92%-97%) | 10.81 (6.43-18.16) | 0.932 |
| - | DNA damage repair pathway | - | 21% (17%-27%) | 95% (91%-97%) | 4.23 (2.01-8.88) | 0.672 |
| - | - | Other pathways | 32% (28%-35%) | 94% (93%-95%) | 7.78 (5.48-11.05) | 0.873 |
| SFRP2 | - | - | 43% (38%-49%) | 94% (91%-97%) | 11.06 (5.77-21.18) | 0.956 |
| - | MGMT | - | 29% (22%-36%) | 93% (87%-96%) | 4.42 (2.18-8.95) | 0.614 |
| - | MLH | - | 8% (4%-16%) | 98% (92%-100%) | 2.35 (0.14-40.83) | - |
| - | - | Vimentin | 23% (17%-31%) | 95% (92%-98%) | 8.30 (2.60-26.55) | 0.898 |
| - | - | OSMR | 25% (14%-39%) | 95% (91%-98%) | 5.20 (1.44-18.82) | 0.817 |
| - | - | P16 | 33% (23%-44%) | 97% (89%-100%) | 13.27 (3.40-51.83) | 0.97 |
| SFRP2 | MLH | - | 34% (29%-39%) | 95% (92%-97%) | 9.62 (4.64-19.93) | 0.947 |
| SFRP2 | MGMT | - | 38% (33%-42%) | 94% (91%-96%) | 7.85 (4.79-12.87) | 0.753 |
| SFRP2 | - | OSMR | 41% (35%-46%) | 95% (92%-96%) | 9.25 (5.13-16.69) | 0.948 |
| SFRP2 | - | Vimentin | 36% (32%-41%) | 95% (93%-96%) | 9.88 (5.55-17.57) | 0.946 |
| SFRP2 | - | P16 | 41% (36%-46%) | 95% (92%-97%) | 10.37 (6.21-17.31) | 0.948 |
| SFRP2 | MGMT | Vimentin | 34% (30%-38%) | 94% (92%-96%) | 7.81 (4.96-12.29) | 0.804 |
| SFRP2 | MGMT | OSMR | 36% (32%-41%) | 94% (92%-96%) | 7.25 (4.61-11.39) | 0.775 |
| SFRP2 | MGMT | P16 | 37% (33%-41%) | 94% (92%-96%) | 7.92 (5.14-12.21) | 0.772 |
| SFRP2 | MLH | Vimentin | 31% (27%-35%) | 95% (93%-97%) | 8.99 (4.95-16.31) | 0.944 |
| SFRP2 | MLH | OSMR | 33% (29%-38%) | 95% (93%-97%) | 8.37 (4.50-15.59) | 0.941 |
| SFRP2 | MLH | P16 | 34% (30%-38%) | 95% (93%-97%) | 9.98 (5.45-18.27) | 0.947 |
SE: Sensitivity; SP: Specificity; DOR: Diagnostic odds ratios; AUC: The area under the curve; MLH: MutL Homologue; MGMT: O-6-Methylguanine-DNA Methyltransferase.