Table 1. Effect of COMT, MAO-A and BDNF genotype on incidence and time to onset of dyskinesias.

	COMT genotype				MAO-A genotype				BDNF genotype
	Met/Met	Val/Met	Val/Val	P value	GG♀ + G♂	GT♀	TT♀ + T♂	P value	Val/Met + Met/Met	Val/Val	P value
Number of cases	70	127	80	n/a	63	36	169	n/a	63+8	153	n/a
Age at PD onset, years	64.0±9.1	62.7±9.3	66.7±9.1	0.51	63.3±9.5	64.2±8.1	63.0±9.3	0.80	64.3±9.4	62.5±8.9	0.14
Disease duration, years	14.0±6.3	14.8±6.5	15.7±6.5	0.26	13.9±5.9	15.6±5.1	14.9±6.7	0.24	14.1±6.2	14.8±5.9	0.31
Time to onset of dyskinesia, years	8.7±4.9	7.9±4.9	8.4±4.2	0.67	8.0±4.3	9.2±5.6	8.0±4.6	0.58	8.1±4.2	7.7±3.9	0.62
Dyskinesia reported, %	58.5	59.6	63.9	0.78*	55.4	75.0	56.2	0.12*	62.0	62.0	>0.90*
Mean daily LED, mg/day	588±304	593±299	520±275	0.30	551±312	551±235	590±299	0.83	497±202	619±335	0.06
Maximum daily LED, mg/day	667±294	846±464	783±424	0.11	710±356	687±316	814±430	0.33	721±374	845±465	0.08

Values are mean ± SD. Statistical analysis was non-parametric Kruskal-Wallis or Mann-Whitney test.

^*p value from a χ² (Fisher’s exact) test.