Figure 5.

Relationship among mitochondrial swelling, metabolic flux/electron transport, and protection. (A) Mitochondrial swellers activate cell respiration. Three metabolic substrates were used: glucose, octanoate, and palmitate. Values indicated above the control bars are actual respiration rates (nmol O₂/min/10⁶ cells). (B) TMZ blocks protection by Dz, Hoe, and leptin in cardiac myocytes metabolizing palmitate. (C) Respiratory activation by leptin in cardiac myocytes metabolizing different substrates. (D) Sensitivity of Dz-induced respiratory activation to Cl^_ channel inhibition. *P < 0.05 (and all bars under brace) vs. control.