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Central role of GSK-3β in protection. (A and B) Protection induced by Li+, SB 216763 (SB2), or SB 415286 (SB4) cannot be reversed by PKC, PI3K, or mTOR inhibitors (A) or by NAC (B), respectively. *P < 0.05 vs. control. (C) Phosphorylation of GSK-3β (serine-9) in cell lysates, caused by pharmacologic PC. The immunoblot data are representative of three independent experiments.
