Figure 3.

Anti-CD28 mAb prevents GVHD lethality. Lethally irradiated B10.BR mice were transplanted with T cell–depleted bone marrow plus supplemental splenocytes from WT B6 donors. B10.BR recipients were treated with anti-CD28 mAb or hamster IgG (A) or with CTLA4-Ig or L6-Ig (B), each at 100 ∝g/mouse every other day for a total of eight doses. The number of mice in each group is indicated in parentheses, and the data were pooled from three replicate experiments for A and one experiment for B. BM, bone marrow.