Figure 7.

T cells deficient for Fas and TNF receptors are susceptible to anti-CD28–induced depletion in vivo. The experiment was conducted as described in Figure 6A. Thy1.2⁺ cells from B6 WT or lpr, p55–/–, and p75–/– triple knock-out (TKO) donors were transplanted into irradiated BALB/c recipients. The absolute numbers of CD4⁺ and CD8⁺ donor T cells are shown. The data represent two replicate experiments.