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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Hematol Oncol Clin North Am. 2014 Jan 21;28(2):217–231. doi: 10.1016/j.hoc.2013.11.001

Figure 2.

Figure 2

The allosteric mechanism of Hb. (A) Oxygen equilibrium (or dissociation) curve of Hb. The normal P50 value is indicated by dashed lines. The left-shift and right-shift in the curves (blue color) are associated with various conditions, including AEHs. (B) Modulation of Hb allosteric transition by synthetic AEHs. Stabilization of either the R-state or T-state (colored blue) has potential therapeutic applications. The “R” represents all identified relaxed states including R2, R3, RR2, RR3, and the classical R.