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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: J Hepatol. 2013 Sep 20;60(2):298–305. doi: 10.1016/j.jhep.2013.09.013

Fig. 3. Hepatic endotoxemic injury in HSC-depleted mice.

Fig. 3

WT-B6 and GFAP-Tg mice (n=4-6) received CCl4 (3 injections) followed by its discontinuation and GCV treatment of 10 days, then subjected to LPS treatment. (A) Histopathology and (B) quantification of TUNEL- positive hepatocytes; (C) serum ALT; and (D) neutrophil infiltration. Compared to CCl4/GCV then LPS-treated B6 mice very few apoptotic hepatocytes were observed in the livers of CCl4/GCV then LPS-treated GFAP-Tg mice; inset shows high magnification of the marked area to show apoptotic HSC.