Table 2.

Birth Defects of the Face and Neck Region and the Urinary System in Children Exposed to Propylthiouracil in Early Pregnancy

Case	Birth (year)	Gender (f/m)	Ga (weeks)	Bw (grams)	Birth defect (ICD-10)		Agea (years)	Contactsb (n)	Surgeryc (yes/no)	Infectiond (yes/no)
Face and neck cases
1	1996	Female	39	3250	DQ188	Face and neck, other specified	1.5	3	Yes	No
2	1997	Male	40	3800	DQ181	Preauricular sinus/cyst	9.9	6	Yes	Yes
3	2003	Male	38	3350	DQ188	Face and neck, other specified	3.4	4	Yes	Yes
4	2004	Male	38	3490	DQ181	Preauricular sinus/cyst	1.6	7	Yes	Yes
5	2005	Female	41	3410	DQ181	Preauricular sinus/cyst	0.7	2	Yes	No
6	2006	Male	39	3210	DQ188	Face and neck, other specified	1.4	2	No	No
7	2007	Female	37	3050	DQ180	Sinus/fistula/cyst of branchial cleft	0.3	8	Yes	Yes
Urinary system cases
8	1997	Male	40	3400	DQ620	Congenital hydronephrosis	0	3	No	No
9	1998	Male	36	2440	DQ610	Single cyst of kidney	0	3	No	No
10	2002	Male	37	2660	DQ642	Posterior urethral valvee	4.2	5	Yes	No
11	2003	Male	39	3200	DQ620	Congenital hydronephrosis	0	2	No	No
12	2005	Male	41	4200	DQ620 DQ622	Congenital hydronephrosisf Megaureter	0.1	11	Yes	Yes
13	2007	Male	37	3230	DQ610 DQ620	Single cyst of kidney Congenital hydronephrosis	0	4	No	No
14	2008	Male	40	3360	DQ620	Congenital hydronephrosis	0.4	6	Yes	Yes

^aAge at diagnosis of the birth defect.

^bNumber of hospital contacts related to the birth defect up to December 31, 2010.

^cRegistration of surgery related to the birth defect up to December 31, 2010.

^dRegistration of a diagnosis of infection or redeemed prescription of antibiotic related to the birth defect up to December 31, 2010.

^eAlso diagnosed with the birth defects DQ540 glandular hypospadia and DQ541 penile hypospadia.

^fAlso diagnosed with the birth defects DQ531 undescended testis and DQ555 aplasia testis.

PTU, propylthiouracil; Ga, gestational age; bw, birth weight; ICD-10, International Classification of Disease, Tenth Revision.