Table 1.
Anthropometrics and laboratory parameters of the 32 adolescents with hepatic steatosis and the 11 obese controls at fasting state: study cohort 1.
| Parameters, mean (SD) | Obese controls | Subjects with steatosis | P value |
|---|---|---|---|
| (<5% by MRS, n = 11) | (>5% by MRS, n = 32) | ||
| Age, years | 14.3 (1.85) | 13.7 (2.65) | 0.443 |
| Male (n, %) | 4 (36.4) | 13 (40.6) | 0.803 |
| Weight (kg) | 82.9 (21.5) | 80.5 (14.9) | 0.967 |
| BMI z-score | 2.00 (0.22) | 2.17 (0.37) | 0.129 |
| ALT (U/L) | 17.8 (7.60) | 49.7 (89.5) | 0.021 |
| AST (U/L) | 21.9 (3.99) | 68.2 (180) | <0.001 |
| Hepatic fat (%) | 3.87 (0.62) | 11.2 (5.27) | <0.001 |
| Glucose (mmol/L) | 5.13 (0.89) | 5.18 (0.90) | 0.978 |
| Insulin (mU/L) | 18.2 (6.69) | 36.2 (30.5) | 0.010 |
| HOMA-IR | 4.06 (1.31) | 8.79 (9.13) | 0.013 |
| hs-CRP (mg/L) | 3.17 (3.44) | 4.98 (5.92) | 0.278 |
BMI: body mass index; ALT: alanine aminotransferase; AST: aspartate aminotransferase; HOMA-IR: homeostatic model assessment for insulin resistance, calculated as fasting glucose (mmol/L) × insulin (mU/L)/22.5; hs-CRP: high sensitivity C-reactive protein.